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What is the difference between wellness and well-being? Wellness is more closely associated with health and prevention, while well-being is related to one's overall happiness. While most of us use the terms well-being and wellness interchangeably, there is a distinctive difference. Well-being refers to a more holistic, whole of life experience, whereas wellness refers to physical health. Well-being is a good feeling condition of existence. A state characterized by your health, happiness, and prosperity. Wellness is the quality or state of being healthy in body and mind, as a result of deliberate effort. At 1440 we foster both.